La comorbilidad en salud mental en los pacientes diagnosticados de enfermedad pulmonar obstructiva crónica

  1. J. Montserrat-Capdevila 1
  2. P. Godoy 1
  3. J.R. Marsal 2
  4. M. Ortega 3
  5. J. Pifarré 1
  6. F. Barbé 1
  1. 1 Universitat de Lleida
    info

    Universitat de Lleida

    Lleida, España

    ROR https://ror.org/050c3cw24

  2. 2 Hospital Universitari Vall d’Hebron, Barcelona, Cataluña, España
  3. 3 Universitat Autònoma de Barcelona
    info

    Universitat Autònoma de Barcelona

    Barcelona, España

    ROR https://ror.org/052g8jq94

Revista:
Semergen: revista española de medicina de familia

ISSN: 1138-3593

Año de publicación: 2020

Número: 1

Páginas: 53-59

Tipo: Artículo

DOI: 10.1016/J.SEMERG.2019.08.002 DIALNET GOOGLE SCHOLAR

Otras publicaciones en: Semergen: revista española de medicina de familia

Resumen

Objetivo La ansiedad y la depresión juegan un papel importante en la enfermedad pulmonar obstructiva crónica aunque son escasos los estudios que han tratado de determinar su asociación con la exacerbación y todavía menos los que han tratado de cuantificar el número de exacerbaciones asociadas. El objetivo del estudio fue estudiar el riesgo de las exacerbaciones asociadas a la de ansiedad y depresión en los pacientes diagnosticados de enfermedad pulmonar obstructiva crónica. Material y métodos Estudio de cohortes prospectivas que analizó los factores asociados a la exacerbación en 512 enfermos durante 2 años. Las exacerbaciones se definieron como moderadas, aquellas que requirieron antibiótico/s y/o corticoides sistémicos; y graves, las que precisaron de hospitalización. Para cada paciente se registró la ansiedad y depresión (Hospital Anxiety and Depression Scale) y se cuantificaron el número de exacerbaciones durante el periodo de seguimiento. Resultados La prevalencia de ansiedad/depresión al inicio del estudio fue del 15,6%. Durante los 2 años de seguimiento la media de exacerbaciones fue de 2,21. Los pacientes que además presentaban ansiedad/depresión al inicio del estudio presentaron una media de exacerbaciones mayor, de 2,8 (p = 0,001). La ansiedad/depresión se asociaron con un mayor número de exacerbaciones moderadas-graves en el análisis ajustado (IRRa = 1,48). Los otros factores de riesgo asociados a un mayor número de exacerbaciones fueron el antecedente de exacerbación grave previa (IRRa = 1,50; la obesidad (IRRa = 1,27); el sobrepeso (IRRa = 1,23); el FEV1 ≤ 77% (IRRa = 0,84); y una mayor disnea (IRRa = 1,14). Conclusiones Los enfermos con ansiedad/depresión presentan un mayor número de exacerbaciones y tienen un 48% más de riesgo de padecer una exacerbación respecto a los enfermedad pulmonar obstructiva crónica sin ansiedad/depresión.

Referencias bibliográficas

  • R.A. Pauwels, A.S. Buist, P.M. Calverley, C.R. Jenkins, S.S. Hurd Global strategy for the diagnosis, management, and prevention of chronic obstructive pulmonary disease. NHLBI/WHO Global Initiative for Chronic Obstructive Lung Disease (GOLD) Workshop summary Am J Respir Crit Care Med., 163 (2001), pp. 1256-1276 CrossRefView Record in ScopusGoogle Scholar
  • J.A. Wedzicha, T.A. Seemungal COPD exacerbations: defining their cause and prevention Lancet., 370 (2007), pp. 786-796 ArticleDownload PDFView Record in ScopusGoogle Scholar
  • D.M. Mannino, K. Higuchi, T.C. Yu, H. Zhou, Y. Li, H. SK. Tian Economic burden of chronic obstructive pulmonary disease by presence of comorbidities Chest, 148 (2015), pp. 138-150 ArticleDownload PDFCrossRefView Record in ScopusGoogle Scholar
  • G.R. Husebø, P.S. Bakke, M. Aanerud, J.A. Hardie, T. Ueland, R. Grønseth, et al. Predictors of exacerbations in chronic obstructive pulmonary disease--results from the Bergen COPD cohort study PLoS One., 9 (2014), p. e109721 CrossRefGoogle Scholar
  • G. Gudmundsson, T. Gislason, C. Janson, E. Lindberg, C. Suppli Ulrik, E. Brøndum, et al. Depression, anxiety and health status after hospitalisation for COPD: a multicentre study in the Nordic countries Respir Med., 100 (2006), pp. 87-93 ArticleDownload PDFView Record in ScopusGoogle Scholar
  • J.H. Jennings, B. Digiovine, D. Obeid, C. Frank The association between depressive symptoms and acute exacerbations of COPD Lung., 187 (2009), pp. 128-135 CrossRefView Record in ScopusGoogle Scholar
  • J. Garcia-Aymerich, E. Farrero, M.A. Félez, J. Izquierdo, R.M. Marrades, J.M. Antó Risk factors of readmission to hospital for a COPD exacerbation: a prospective study Thorax., 58 (2003), p. 100 View Record in ScopusGoogle Scholar
  • S. Peruzza, G. Sergi, A. Vianello, C. Pisent, F. Tiozzo, A. Manzan, et al. Chronic obstructive pulmonary disease (COPD) in elderly subjects: impact on functional status and quality of life Respir Med., 97 (2003), pp. 612-617 ArticleDownload PDFView Record in ScopusGoogle Scholar
  • M.J. Herrero, J. Blanch, J.M. Peri, J. de Pablo, L. Pintor, A. Bulbena A validation study of the hospital anxiety and depression scale (HADS) in a Spanish population Gen Hosp Psychiatry., 25 (2003), pp. 277-283 ArticleDownload PDFView Record in ScopusGoogle Scholar
  • W. Xu, J.-P. Collet, S. Shapiro, Y. Lin, T. Yang, R.W. Platt, et al. Independent effect of depression and anxiety on chronic obstructive pulmonary disease exacerbations and hospitalizations Am J Respir Crit Care Med., 178 (2008), pp. 913-920 View Record in ScopusGoogle Scholar
  • M. Miravitlles, J. Molina, J.A. Quintano, A. Campuzano, J. Pérez, C. Roncero, et al. Factors associated with depression and severe depression in patients with COPD Respir Med., 108 (2014), pp. 1615-1625 ArticleDownload PDFView Record in ScopusGoogle Scholar
  • G. Gudmundsson, T. Gislason, C. Janson, E. Lindberg, R. Hallin, C.S. Ulrik, et al. Risk factors for rehospitalisation in COPD: role of health status, anxiety and depression Eur Respir J., 26 (2005), pp. 414-419 CrossRefView Record in ScopusGoogle Scholar
  • T.-P. Ng, M. Niti, W.-C. Tan, Z. Cao, K.-C. Ong, P. Eng Depressive symptoms and chronic obstructive pulmonary disease: effect on mortality, hospital readmission, symptom burden, functional status, and quality of life Arch Intern Med., 167 (2007), pp. 60-67 CrossRefView Record in ScopusGoogle Scholar
  • M.E. Kunik, K. Roundy, C. Veazey, J. Souchek, P. Richardson, N.P. Wray, et al. Surprisingly high prevalence of anxiety and depression in chronic breathing disorders Chest., 127 (2005), pp. 1205-1211 ArticleDownload PDFCrossRefView Record in ScopusGoogle Scholar
  • Global Initiative for Chronic Obstructive Pulmonary Disease (GOLD). Global Strategy for Diagnosis, Management and Prevention of COPD. 2016. Google Scholar
  • K.F. Rabe, S. Hurd, A. Anzueto, P.J. Barnes, S.A. Buist, P. Calverley, et al. Global strategy for the diagnosis, management, and prevention of chronic obstructive pulmonary disease: GOLD executive summary Am J Respir Crit Care Med., 176 (2007), pp. 532-555 View Record in ScopusGoogle Scholar
  • M.E. Charlson, P. Pompei, K.L. Ales, C.R. MacKenzie A new method of classifying prognostic comorbidity in longitudinal studies: development and validation J Chronic Dis., 40 (1987), pp. 373-383 ArticleDownload PDFView Record in ScopusGoogle Scholar
  • J.C. Bestall, E.A. Paul, R. Garrod, R. Garnham, P.W. Jones, J.A. Wedzicha Usefulness of the Medical Research Council (MRC) dyspnoea scale as a measure of disability in patients with chronic obstructive pulmonary disease Thorax., 54 (1999), pp. 581-586 CrossRefView Record in ScopusGoogle Scholar
  • J.J. Soler-Cataluña, M.A. Martínez-García, L.S. Sánchez, M.P. Tordera, P.R. Sánchez Severe exacerbations and BODE index: two independent risk factors for death in male COPD patients Respir Med., 103 (2009), pp. 692-699 ArticleDownload PDFView Record in ScopusGoogle Scholar
  • P.W. Jones, G. Harding, P. Berry, I. Wiklund, WH KLN. Chen Development and first validation of the COPD Assessment Test Respir J., 34 (2009), pp. 648-654 CrossRefView Record in ScopusGoogle Scholar
  • J.R. Hurst, J. Vestbo, A. Anzueto, N. Locantore, H. Müllerova, R. Tal-Singer, et al. Susceptibility to exacerbation in chronic obstructive pulmonary disease N Engl J Med., 363 (2010), pp. 1128-1138 View Record in ScopusGoogle Scholar
  • J.K. Quint, R. Baghai-Ravary, G.C. Donaldson, J.A. Wedzicha Relationship between depression and exacerbations in COPD Eur Respir J Off J Eur Soc Clin Respir Physiol., 32 (2008), pp. 53-60 CrossRefView Record in ScopusGoogle Scholar
  • M.W.B. Zhang, R.C.M. Ho, M.W.L. Cheung, E. Fu, A. Mak Prevalence of depressive symptoms in patients with chronic obstructive pulmonary disease: a systematic review, meta-analysis and meta-regression Gen Hosp Psychiatry., 33 (2011), pp. 217-223 ArticleDownload PDFView Record in ScopusGoogle Scholar
  • J.G. Van Manen, P.J.E. Bindels, F.W. Dekker, C.J. IJzermans, J.S. van der Zee, E. Schadé Risk of depression in patients with chronic obstructive pulmonary disease and its determinants Thorax., 57 (2002), pp. 412-416 View Record in ScopusGoogle Scholar
  • T.G. Willgoss, A.M. Yohannes Anxiety disorders in patients with COPD: a systematic review Respir Care., 58 (2013), pp. 858-866 View Record in ScopusGoogle Scholar
  • P.A. Coventry, P. Bower, C. Keyworth, C. Kenning, J. Knopp, C. Garrett, et al. The effect of complex interventions on depression and anxiety in chronic obstructive pulmonary disease: systematic review and meta-analysis PLoS One., 8 (2013), p. e60532 CrossRefGoogle Scholar
  • S.D. Ramsey, F.D.R. Hobbs Chronic obstructive pulmonary disease, risk factors, and outcome trials: comparisons with cardiovascular disease Proc Am Thorac Soc., 3 (2006), pp. 635-640 CrossRefView Record in ScopusGoogle Scholar
  • B.R. Celli, C.G. Cote, J.M. Marin, C. Casanova, M. Montes de Oca, R.A. Mendez, et al. The body-mass index, airflow obstruction, dyspnea, and exercise capacity index in chronic obstructive pulmonary disease N Engl J Med., 350 (2004), pp. 1005-1012 View Record in ScopusGoogle Scholar
  • A. Pooler, R. Beech Examining the relationship between anxiety and depression and exacerbations of COPD which result in hospital admission: a systematic review Int J Chron Obstruct Pulmon Dis., 9 (2014), pp. 315-330 View Record in ScopusGoogle Scholar
  • J.M. Marin, S.J. Carrizo, C. Casanova, P. Martinez-Camblor, J.B. Soriano, A.G.N. Agusti, et al. Prediction of risk of COPD exacerbations by the BODE index Respir Med., 103 (2009), pp. 373-378 ArticleDownload PDFView Record in ScopusGoogle Scholar
  • C. Martinez Rivera, J. Costan Galicia, B. Alcázar Navarrete, C. Garcia-Polo, L.A. Ruiz Iturriaga, A. Herrejón, et al. Factors Associated with Depression in COPD: A Multicenter Study Lung., 194 (2016), pp. 335-343 CrossRefView Record in ScopusGoogle Scholar