MANUEL
PORTERO OTIN
CU
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Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas
Madrid, EspañaPublications in collaboration with researchers from Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (28)
2023
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Ether Lipid-Mediated Antioxidant Defense in Alzheimer’s Disease
Antioxidants, Vol. 12, Núm. 2
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Lipid Adaptations against Oxidative Challenge in the Healthy Adult Human Brain
Antioxidants, Vol. 12, Núm. 1
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Lipidomic Alterations in the Cerebral Cortex and White Matter in Sporadic Alzheimer’s Disease
Aging and Disease, Vol. 14, Núm. 5, pp. 1887-1916
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Sphingolipid desaturase DEGS1 is essential for mitochondria-associated membrane integrity
The Journal of clinical investigation, Vol. 133, Núm. 10
2022
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Activating cannabinoid receptor 2 preserves axonal health through GSK-3β/NRF2 axis in adrenoleukodystrophy
Acta Neuropathologica, Vol. 144, Núm. 2, pp. 241-258
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Selective brain regional changes in lipid profile with human aging
GeroScience, Vol. 44, Núm. 2, pp. 763-783
2021
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Age-related changes in lipidome of rat frontal cortex and cerebellum are partially reversed by methionine restriction applied in old age
International Journal of Molecular Sciences, Vol. 22, Núm. 22
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Lipid alterations in human frontal cortex in ALS-FTLD-TDP43 proteinopathy spectrum are partly related to peroxisome impairment
Neuropathology and Applied Neurobiology, Vol. 47, Núm. 4, pp. 544-563
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Lipidomic traits of plasma and cerebrospinal fluid in amyotrophic lateral sclerosis correlate with disease progression
Brain Communications, Vol. 3, Núm. 3
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Nuclear lipidome is altered in amyotrophic lateral sclerosis: A pilot study
Journal of Neurochemistry, Vol. 158, Núm. 2, pp. 482-499
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The causal role of lipoxidative damage in mitochondrial bioenergetic dysfunction linked to alzheimer’s disease pathology
Life, Vol. 11, Núm. 5
2018
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Aberrant regulation of the GSK-3β/NRF2 axis unveils a novel therapy for adrenoleukodystrophy
EMBO Molecular Medicine, Vol. 10, Núm. 8
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Lipid Profile in Human Frontal Cortex Is Sustained Throughout Healthy Adult Life Span to Decay at Advanced Ages
Journals of Gerontology - Series A Biological Sciences and Medical Sciences, Vol. 73, Núm. 6, pp. 703-710
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Regional vulnerability to lipoxidative damage and inflammation in normal human brain aging
Experimental Gerontology, Vol. 111, pp. 218-228
2017
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Loss of SIRT2 leads to axonal degeneration and locomotor disability associated with redox and energy imbalance
Aging Cell, Vol. 16, Núm. 6, pp. 1404-1413
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Region-specific vulnerability to lipid peroxidation and evidence of neuronal mechanisms for polyunsaturated fatty acid biosynthesis in the healthy adult human central nervous system
Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids, Vol. 1862, Núm. 5, pp. 485-495
2016
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Redox proteomic profiling of neuroketal-adducted proteins in human brain: Regional vulnerability at middle age increases in the elderly
Free Radical Biology and Medicine, Vol. 95, pp. 1-15
2015
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Deregulation of purine metabolism in Alzheimer's disease
Neurobiology of Aging, Vol. 36, Núm. 1, pp. 68-80
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Lipidomics of Human Brain Aging and Alzheimer's Disease Pathology
International Review of Neurobiology (Academic Press Inc.), pp. 133-189
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Neuroinflammatory gene regulation, mitochondrial function, oxidative stress, and brain lipid modifications with disease progression in tau P301S transgenic mice as a model of frontotemporal lobar degeneration-tau
Journal of Neuropathology and Experimental Neurology, Vol. 74, Núm. 10, pp. 975-999